Healthy Veterans Project, LLC

Plus Relief represents a novel, science-based advancement in the management of chronic pain among veterans. Developed through extensive research and clinical innovation, Plus Relief is specifically formulated to address the limitations and risks associated with conventional analgesics such as opioids and NSAIDs.

Utilizing cobra-venom–derived peptides, Plus Relief acts on Alpha-7 nicotinic acetylcholine receptors (α7 nAChRs) — key mediators of pain and inflammation within the nervous system. By selectively modulating these receptors, Plus Relief interrupts the underlying neuro-inflammatory processes that drive chronic and injury-related pain, offering targeted and sustained symptom relief without the systemic burden of traditional pharmacotherapies.

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Distinguishing Mechanisms and Benefits

• Induced-Fit Binding Mechanism: Plus Relief demonstrates an adaptive receptor-binding process that enhances therapeutic efficiency with continued use. Over time, receptor sites conform to the peptides’ molecular structure, enabling equal or improved analgesic outcomes at progressively lower dosages. This contributes to a more stable and sustainable dosing profile over the course of treatment.

• Non-Opioid, Non-NSAID Profile: By eliminating reliance on opioid and NSAID pathways, Plus Relief reduces the risk of dependency, gastrointestinal complications, renal impairment, and other adverse effects associated with these drug classes.

• Targeted and Sustained Relief: The peptide-based modulation of α7 nAChRs provides durable inhibition of pain signaling, supporting improved functional outcomes and enhanced quality of life for veterans with chronic pain conditions.

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Clinical Relevance for VA Providers

Plus Relief aligns directly with the VA’s strategic initiatives to expand access to non-opioid, evidence-based pain management solutions. Its unique mechanism of action offers clinicians an opportunity to improve outcomes in patients experiencing chronic, inflammatory, or injury-related pain while minimizing pharmacologic risk.

Key clinical advantages include:

• Reduction in opioid and NSAID utilization rates

• Enhanced long-term pain control through receptor-level modulation

• Improved patient safety and adherence due to lower side-effect burden

• Sustainable cost-efficiency across chronic treatment regimens

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For VA providers, Plus Relief offers a novel, mechanism-driven approach to pain management — one that supports the broader mission of delivering safe, effective, and responsible care to those who have served.

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Our Mission and Core Values

At Healthy Veterans Project, our mission is to identify, evaluate, and promote the most advanced therapeutic solutions for the veteran community. We are dedicated to supporting healthcare providers with the education, clinical insight, and implementation tools necessary to integrate these innovations into evidence-based care protocols.

Core Values

• Integrity: Upholding the highest standards of scientific and clinical transparency.

• Innovation: Advancing veteran healthcare through the application of novel biomedical technologies.

• Compassion: Delivering patient-centered solutions that respect the unique challenges of the veteran population.

• Collaboration: Partnering with providers to ensure effective adoption and ongoing support of new therapeutic modalities.